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If psychopathology predates drug usage, LSD exacerbates these disturbances, including violent outbursts e. At present, LSD use is not epidemic and no new information has become available to evaluate the significance of the LSD-violence link. LSD is not of significance in the present violence discussion. The older literature suggests that certain psychopathological individuals who begin using LSD may engage in violent acts; however, this phenomenon is rare. PCP was introduced as synthetic surgical anesthetic in , was withdrawn from human use because it induced psychotic reactions.

Repetitive, prolonged, and unusual acts of violence by individuals intoxicated with PCP have attracted considerable attention in the media e. In the limited studies with animals, acutely administered PCP has been found to have unpredictable effects on aggressive behavior. Some studies find PCP to disrupt aggressive and defensive behavior engendered by painful stimuli, isolated housing, or territorial defense see Table 12 , section C.

However, in other samples, PCP may increase some aspects of aggressive behavior in mice, rats, and squirrel monkeys e. In selected individuals, acute PCP has dose-dependent biphasic effects, with low doses increasing and high doses decreasing aggressive behavior Miczek and Haney, in press. Notably, PCP-treated mice and stumptail macaque monkeys become the targets of more frequent aggressive behavior by drug-free opponents or group members, presumably due to inappropriate social signals, provocative actions, and hyperactivity e.

In view of the use pattern in humans, it is surprising that no studies on chronic PCP and aggressive behavior in animals have been conducted.


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In humans, PCP is usually part of polydrug use, including alcohol; therefore it is difficult to dissect the PCP-specific effects, especially those on aggressive and violent behavior e. No experimental studies on PCP and human violence or aggression have been conducted. As summarized in Table 13 , clinical reports from emergency rooms or psychiatric hospital settings indicate a prevalence of PCP psychosis and analgesia, and it is in this context that PCP-associated violence appears most often.

Reports from different localities in the United States over the past two decades refer to cases of chronic PCP-induced psychosis that also include agitation, physical assaults, self-directed injuries, and homicidal activities due to poor judgment, panic reactions, and imagined frustrations e. Overall these cases are relatively infrequent, but stand out by their bizarre and repulsive, stereotyped, repetitive nature.

Physical or pharmacologic restraint of PCP-agitated individuals is difficult to manage clinically. Since the neurobiologic action of PCP is only beginning to be identified with the characterization. Until that time, clinicians resort to antipsychotic drugs in order to manage PCP psychosis see especially Smith and Wesson, , and reviews in Table It does not magically produce violent, assaultive, or criminal behavior" Siegel, Generally, personality predispositions and a history of violent behavior appear to determine whether or not PCP intoxication leads to violence.

PCP violence is a relatively rare phenomenon, although it stands out by its highly unusual form and intensity, and it depends on the social and personal background of the individual. Drugs produce some of their effects on violent and aggressive behavior via action on the central nervous system. This action, however, can modify neural functions in a very intricate way and at multiple levels that ultimately target aggression-specific brain mechanisms.


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Alcohol and drugs of abuse do not engender violent behavior in every individual, and many imbibe alcoholic beverages or self-administer drugs without becoming violent. The impact of genetic predispositions to be susceptible to dependence-producing drugs such as alcohol, heroin, or cocaine and to act violently has, as of yet, not been delineated in terms of specific neural mechanisms. Similarly, the modulating influences of learning, social modeling, or parental physical abuse on the neural substrate for drug action and for aggressive behavior and impulse control have not been specified.

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Since these critical connections remain ill understood, it is not possible at present to propose specific modes of intervention at the neurobiologic level. Alcohol is the drug that is most prevalent in individuals committing violence and those who are victims of violence. This association applies to various types of violent behavior and aggressive tendencies. Experimental studies have repeatedly demonstrated that alcohol causes an increase in aggressive behavior, in both animals and humans. Despite its apparent limitations, laboratory research represents the primary avenue to delineate the causative relationship among alcohol, aggression, and violence.

Alcohol's action on the brain mechanisms for aggressive behavior is modulated by genetic predispositions, learned expectations, social restraints, and cultural habits. Recent progress in understanding the actions of alcohol on brain serotonin and GABA systems may eventually offer diagnostic tools for individuals at risk and therapeutic options for intervention. The violence associated with cocaine-crack is substantially different in nature and context from the aggression-enhancing effects of alcohol. Violent behavior under the influence of amphetamines, cocaine, LSD, and PCP is rare in the general population, but is considerably more likely in those individuals whose psychopathology predates the drug use.

Significantly, most of the violence associated with cocaine and narcotic drugs results from the business of supplying, dealing, and acquiring these substances, not from the direct neurobiologic actions of these drugs. We need to identify those individuals in whom either alcohol, opiates, cocaine, amphetamines, PCP, LSD, or other hallucinogens promote violent and aggressive behavior by attending to the precise pharmacologic conditions at the time of the violent act; the individual's physiologic conditions; the genetic, developmental, and social background; and the prevailing social conditions.

Clearly, alcohol and other drugs of abuse differ markedly from each other in terms of pharmacology and neurobiologic mechanisms, dependence liability, legal and social restraints, expectations, and cultural traditions; no general and unifying principle applies to all of these substances.

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It should not be surprising that the conditions that promote violence in individuals under the influence of alcohol cannot be simply extrapolated to cocaine-crack or to narcotic drugs. Rational intervention strategies need to be based on an adequate understanding of the specific circumstances, individuals, and pharmacologic conditions that are implicated in any specific type of violent act. Abel, E. British Journal of Addiction Psychological Bulletin Zeidenberg Age, alcohol and violent death: A postmortem study.

Journal of Studies on Alcohol Strasburger, and P. Zeidenberg Seasonal, monthly, and day-of-week trends in homicide as affected by alcohol and race. Alcoholism: Clinical and Experimental Research Abramson, H. Evans Lysergic acid diethylamide LSD Psychobiological effects on the Siamese fighting fish. Science Albert, D.

Walsh The inhibitory modulation of agonistic behavior in the rat brain: A review. Neuroscience and Biobehavioral Reviews Al Hazmi, M.

Brain Effects of age, habituation and alcohol administration on tube restraint-induced attack by Swiss mice abstract. Aggressive Behavior Allen, J.

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West Flight from violence: Hippies and the green rebellion. American Journal of Psychiatry Allen, R. Safer, and L. Covi Effects of psychostimulants on aggression. Journal of Nervous and Mental Disease Alves, C. Carlini Effects of acute and chronic administration of Cannabis sativa extract on the mouse-killing behavior of rats. Life Sciences Goyos, and E. Carlini Aggressiveness induced by marihuana and other psychotropic drugs in REM sleep deprived rats. Pharmacology Biochemistry and Behavior Anderson, A.

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Journal of Clinical Psychiatry Anggard, E. Lader, ed. Oxford: Oxford University Press. Anglin, M. Hser Addicted women and crime. Criminology Speckart Narcotic use and crime: A multisample, multimethod analysis. Angrist, B. Gershon Amphetamine abuse in New York City Seminars in Psychiatry Comprehensive Psychiatry Apfeldorf, M. Journal of Clinical Psychology Archer, J. Cambridge: Cambridge University Press.

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Kirilcuk, S. Corson, and E. Corson Levoamphetamine and dextroamphetamine: Differential effect on aggression and hyperkinesis in children and dogs. Atkinson, J. Postgraduate Medicine Avis, H. Peeke Differentiation by morphine of two types of aggressive behavior in the convict cichlid Cichlasoma nigrofasciatum. Psychopharmacologia Babor, T. Mendelson, D.