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Discussion: Mast cell disorders are known to predispose to osteoporosis, as well as vertebral compression fractures and in a few patients diffuse sclerotic changes. This case highlights symptomatic bony sclerosis, which can be confused with metastatic disease associated with this condition. Further studies are required to substantiate this potential association.

With both diagnoses, the prostate is affected; however, the etiology of the disease is different. The purpose of this study was to study the characteristics of the humoral immunity in patients with adenoma and prostate cancer relative to the control group. Method: 90 patients with adenoma, 47 patients with prostate cancer and healthy individuals were examined. Statistical data processing was performed using Statistica for Windows 8. In patients with prostate adenoma, there was a decrease in IgM relative to the control group.

IgA values increased in patients with adenoma and prostate cancer in relatively healthy individuals, but the data were not statistically significant. Background: The aim of this study was to investigate the serum lipid metabolomic differences between patients with allergic asthma and healthy controls, and analysis of changes in serum arachidonic acid metabolism in allergic asthma patients with conventional drug therapy and specific immunotherapy respectively. Method: 49 patients with allergic asthma were enrolled in the asthma group, and another 15 healthy individuals were recruited as the healthy group.

Metabolic pathway enrichment analysis showed that differential metabolites are concentrated in arachidonic acid metabolic pathways, and this pathway is mostly associated with inflammatory reactions and oxidative stress. Conclusion: This suggested that HETEs were the potential biomarkers of asthma and Gpx4 might play important role in the regulation of the content of HETEs in asthma human serum, and may be used as biological indicators of therapeutic monitoring during SCIT treatment. Tsai H 1 , Yao T 2,3. Background: Asthma is a common disease in pediatric populations.

It affects approximately million people worldwide. Fraction of exhaled nitric oxide FeNO is recognized as a clinical marker of airway inflammation. However, it remains unclear whether childhood FeNO levels can be served as a predictor of subsequent asthma symptoms in adolescence. This study aims to investigate the relationship between childhood FeNO levels and subsequent asthma symptoms in adolescence. Multiple logistic regression models with covariates adjustment were carried out to evaluate the association of between childhood FeNO levels and longitudinal change of asthma symptoms in adolescence.

Results: A total of study children were included. Among those, there were 54 4.

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Conclusion: Our results indicate positive associations between childhood FeNO levels and longitudinal change of asthma symptoms in adolescence. Background: Chronic airway inflammation is a major factor of asthma pathophysiology. The estimation of the airway inflammation in asthma is based on complicated and invasive methods: bronchial biopsies and bronchial alveolar lavage. The diagnosis was based on clinical history, physical findings and lung function tests.

Results: The oxidative stress markers were assessed both in peripheral blood and in EBC. Conclusion: Asthma pathophysiology is directly associated with oxidative stress. Exhaled breath condensate is only partially useful to assess airway inflammation. Respiratory function and bronchodilator responsiveness were measured by standard spirometry.

Background: In the past years, novel biological treatment options for severe asthma have emerged. In order to be able to offer these therapies to the suitable patients, it is mandatory to characterize these patients by detailed phenotyping. Several new agents are used in the treatment of severe eosinophilic asthma, which makes it important to demonstrate eosinophilic airway inflammation. The purpose of this study was to evaluate if the standard blood sample eosinophilic granulocyte count corresponds to the measurement of the fraction of exhaled Nitric Oxide FeNO and induced sputum eosinophils.

Method: We retrospectively evaluated blood eosinophils, FeNO and sputum eosinophils in 58 consecutive patients, where induced sputum was obtained.


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Results for these biomarkers were evaluated by dividing results in those in the normal range and increased values. Relative risk ratios RR and odds ratio OR were then calculated. Correlation between blood and sputum eosinophils was observed: RR of 2. These individuals represent a group who would not be offered biological treatment for severe eosinophilic asthma, potentially beneficial to them. Conclusion: Eosinophilic sputum count is an important biomarker in severe eosinophilic asthma and may identify patients suitable for biological treatment, who are not detected by measurement of blood eosinophils or FeNO.

This approach is not only useful in differentiation between various asthma mechanisms endotypes but is also a prerequisite for a personalized medicine and an improvement of treatment efficacy. The aim of the study was to characterise different types of asthma 1 atopic vs nonatopic 2 eosinophilic vs noneosinophilic based on sputum cytokine profile. Total and differential cell counts in IS were assessed and the concentration of 35 cytokines were measured in sputum supernatant by Luminex platform or ELISA assay.

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Spirometry and bronchodilator reversibility was performed. Atopy was assessed with skin prick testing. Total IgE was measured in serum. Background: Periostin, a matricellular protein detectable in serum of patients with asthma has a strong association with disease severity. The clinical evaluation included the presence of symptoms, the number of exacerbation in the last year and disease severity.

Periostin was significantly higher in patients with asthma [median Periostin was not correlated with disease severity or spirometric parameters. Periostin may play a role in evaluation of asthma severity and clinical stage of disease, but not in COPD patients. Gasiuniene E , Sitkauskiene B. Background: Asthma heterogeneity has been revealed with the recognition of multiple pathways, mediators, and systems involved in triggering the characteristic airway inflammation and variable airflow limitation.

Asthma can be divided into various distinct phenotypes based on clinical characteristics, physiological findings, and triggers. Method: Cluster analysis was performed in R v3. A total of adults patients with asthma diagnosed according to recommendations of GINA were recruited to the study.

To minimize bias, smoking status and years of smoking were not included in the analysis. Data normality was checked with histograms and QQ plots. Hierarchical clustering was performed using Ward's linkage with Ward's clustering criterion.

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The optimal number of clusters was validated using the Dunn criterion as well as by comparing different clustering algorithms using the clValid package. Conclusion: Analysis of Lithuanian asthma cohort study showed that patients vary by atopy, the age of disease onset, clinical, physiological, and inflammatory characteristics and three predominant clusters were identified. These inflammatory phenotypes can be further analyzed in selecting targeted therapeutics and identifying preventative strategies. Background: Severe asthma is a heterogeneous disease consisting of different endotypes and inflammatory characteristics.

Blood eosinophils Eos were measured by automatic haemoanalyser and serum total IgE levels were assessed by immunofluorescence assay. Eosinophil blood count is the most frequently elevated biomarker. There is an overlap between indications for prescription of different biologicals in patients with severe asthma. Background: Asthma is a heterogeneous and chronic inflammatory disorder. Eosinophil is a major inflammatory cell involved in the pathophysiology of asthma.

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Sputum eosinophil is associated with disease severity, treatment outcome, and prognosis in asthma patients. However, it is less known of the relation between blood eosinophil and asthma. We investigated the clinical features of bronchial asthma according to blood eosinophil count.

There was no significant difference in change of ICS dosage according to blood eosinophil count in asthmatics. Background: The fractional concentrations of exhaled nitric oxide FeNO have been elevated only in subjects with atopic asthma which is common in childhood. We sought to determine if methacholine challenge test could be replaced by FeNO measurement.

In our study, the two tests are mutually complementary in pediatric asthma. Many factors can influence asthma control, including allergen exposure, which may vary greatly with climatic and seasonal changes.